منابع مشابه
Vismodegib: a review.
In January 2012, vismodegib (Erivedge, manufactured by Genentech) became the first selective inhibitor of the Hedgehog signaling pathway to be approved by the US Food and Drug Administration for the treatment of locally advanced and metastatic basal cell carcinoma. The drug selectively binds to Smoothened, a 7-helix transmembrane receptor, thereby inhibiting activation of transcription factors ...
متن کاملCCR Drug Updates Vismodegib
Vismodegib (GDC-0449), an orally bioavailable small-molecule inhibitor of Hedgehog signaling, was recently approved by the U.S. Food and Drug Administration for the treatment of basal cell carcinoma that is either metastatic or locally advanced in patients who are not candidates for surgical resection or radiation. Given the absence of previously defined effective drug therapy for this disease,...
متن کاملVismodegib (erivedge) for advanced Basal cell carcinoma.
Vismodegib (Erivedge) for advanced basal cell carcinoma.
متن کاملVismodegib in the treatment of advanced BCC.
Basal-cell carcinoma (BCC) is the most commonly diagnosed malignancy, comprising over 80 per thousand of non-melanoma skin cancers. Surgical excision is adequate treatment for most BCC's. Options are however limited for the minority of patients presenting with locally advanced inoperable or metastatic BCC. The Hedgehog signalling pathway is a critical driver in the pathogenesis of both sporadic...
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No. 2.362. American Epilepsy Society Annual Meeting, 2016. Available at: https://www.aesnet.org. Accessed February 14, 2017. 9. GW Pharmaceuticals. Sativex. Available at: https://www. gwpharm.com/products-pipeline/sativex. Accessed December 5, 2016. 10. National Academies of Sciences, Engineering, and Medicine. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and R...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2012
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3753